Mifepristone Tablets – Prescription Medication for Reproductive Health in Pakistan

Mifepristone is a synthetic steroid medication primarily used in reproductive healthcare for medical termination of early pregnancy. The drug works by blocking the hormone progesterone, which is required to maintain pregnancy. Without progesterone, the uterine lining breaks down, and the pregnancy cannot continue.

What Is Mifepristone?

Mifepristone is a progesterone receptor antagonist. It works by:

• Preventing progesterone from maintaining the uterine lining

• Causing the detachment of the embryo

• Softening the cervix to prepare for expulsion of pregnancy tissue

Medical Uses of Mifepristone:

1. Medical Abortion – Early pregnancy termination up to 10 weeks (used with Misoprostol)

2. Hormonal Disorders – Certain cases like Cushing’s syndrome or fibroids (rare and supervised)

3. Reproductive Health Management – May be used to manage specific conditions as per physician guidance

Mifepristone is not a contraceptive and should not be used as a regular method to prevent pregnancy.

How Mifepristone Works

Mifepristone operates at the molecular level by blocking progesterone receptors, leading to:

1. Uterine Lining Breakdown

   • Progesterone is essential for maintaining the endometrial lining. Mifepristone prevents this, leading to pregnancy termination.

2. Cervical Softening

   • The medication facilitates cervical dilation, which, in combination with Misoprostol, allows for the safe expulsion of pregnancy tissue.

3. Induction of Uterine Contractions

   • When paired with Misoprostol, Mifepristone triggers uterine contractions, completing the termination process.

The combined effect is a medically supervised, non-surgical abortion method that is widely used globally.

Key Benefits

• Effective Early Pregnancy Termination – Up to 10 weeks gestation when used with Misoprostol

• Non-Surgical Method – Avoids surgical procedures when medically appropriate

• Safe When Supervised – Low complication rates under professional guidance

• Controlled Dosage – Specific dosage ensures predictable outcomes

• Reproductive Health Management – May support certain hormonal disorders

Ingredients / Composition

Active Ingredient:

• Mifepristone 200 mg per tablet

Inactive Ingredients:

• Microcrystalline cellulose

• Lactose monohydrate

• Magnesium stearate

• Povidone

• Other excipients for tablet formation

All ingredients are pharmaceutical grade and approved by regulatory authorities.

Who Should Use Mifepristone

Mifepristone is intended for use only by adult women under strict medical supervision.

• Women seeking medically supervised early pregnancy termination

• Patients under prescription for specific hormonal disorders (rare)

Contraindications:

• Pregnancy beyond recommended gestation (typically 10 weeks)

• Chronic adrenal failure

• Uncontrolled bleeding disorders

• Allergy to Mifepristone or excipients

• Ectopic pregnancy

Always consult a licensed physician before use.

How to Use

Mifepristone should always be administered under a physician’s guidance:

1. Take the 200 mg tablet orally as prescribed

2. Wait 24–48 hours, then take Misoprostol as instructed

3. Monitor for bleeding, cramping, or side effects

4. Follow-up with a healthcare provider to confirm completion

Do not self-administer or purchase from unverified sources. Improper use can cause serious complications.

Safety and Side Effects

Common Side Effects:

• Nausea and vomiting

• Fatigue

• Mild fever or chills

• Abdominal cramps

• Vaginal bleeding

Serious Side Effects (require medical attention):

• Excessive bleeding

• Severe abdominal pain

• Signs of infection (fever, foul-smelling discharge)

• Incomplete abortion

Important: Misuse can be life-threatening. Only take under licensed medical supervision.

Legal and Regulatory Information

In Pakistan, Mifepristone is a controlled prescription-only medication. Purchase and use are allowed only under medical authorization. Unauthorized sale, purchase, or self-use may violate local laws.